Nick DeMello, Ph.D.

Nick DeMello, Ph.D.

Chemistry Teacher · Stanford Online High School

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Background

Nick received his chemistry B.S. from UC Berkeley and Ph.D. from the University of Pittsburgh. His research with Dennis Curran included the design of a programmable chiral auxiliary, algorithms for optimizing stereo-selection in free radical reactions, and the development of molecular mechanics parameters that have since been incorporated into the industry standard software MacroModel.

Post-doctoral quantum chemistry research with Ken Houk at UCLA focused on building molecular mechanics models for the transition state of epoxidation reactions and developing new technologies for molecular visualization.

Molecular visualization created by Nick DeMello

Molecular visualization created by Nick DeMello

Digital Innovation & Industry

A founding member of the UCLA Center for Digital Innovation (CDI) that brought together Hollywood production professionals, Silicon Valley software developers, and university-level educators, the CDI produced some of the first distance learning products. Nick's projects included work for the University of California, McGraw-Hill, the Ministry of Education of Malaysia, Sony Corporation, Hitachi Ltd, and the development of CyberChem — McGraw-Hill's best-selling distance learning product.

Using software of his own design, Nick developed molecular illustrations for the cover of Science Magazine, C&E News, Angewandte Chemie, Eyes on Chemistry, Genes & Development, the calendar of the American Chemical Society, and other publications.

Nick has worked at Lawrence Berkeley Laboratories and Design Science (the creators of MathType and the Equation Editor in every modern word processing program). He served as the editor-in-chief of MacTech Magazine, managed the largest retail presence at every MacWorld Expo for half a decade, and independently developed multimedia content under contract for Apple Inc. and others.

Current Research

Current research projects at Stanford University Online High School include improved algorithms for adaptive learning exercises, student assessment through machine learning, and a toolkit applying augmented reality for molecular visualization.

Selected Publications

Stereoselection at the Steady State by Stereoconvergent Reaction Topography
Journal of the American Chemical Society
DeMello, N. C., Curran, D. P. · 1998; 120 (2): 329–341
Origins of Regioselectivity in Radical Reactions of Axially Twisted Anilides
Journal of the Chemical Society, Chemical Communications
Curran, D. P., DeMello, N. C. · 1993: 1314–1317
Rotational Features of Carbon-Nitrogen Bonds in N-aryl Maleimides
Tetrahedron
Curran, D. P., Geib, S., DeMello, N. · 1999; 55 (18): 5681–5704
Stereoselection at the Steady State. Group Selective Radical Cyclizations
Journal of the American Chemical Society
Curran, D. P., Lin, C. H., DeMello, N., Junggebauer, J. · 1998; 120 (2): 342–351
Transition States of Epoxidations: Diradical Character, Spiro Geometries, Transition State Flexibility, and the Origins of Stereoselectivity
Journal of the American Chemical Society
Houk, K. N., Liu, J., DeMello, N. C., Condroski, K. R. · 1997; 119 (42): 10147–10152
Substrate-Controlled Group-Selective Radical Cyclizations — A New Strategy For Stereocontrolled Transformations of Diastereomeric Reactive Intermediates
Journal of the American Chemical Society
Curran, D. P., Qi, H. Y., DeMello, N. C., Lin, C. H. · 1994; 116 (18): 8430–8431
Atroposelective Thermal-Reactions of Axially Twisted Amides and Imides
Journal of the American Chemical Society
Curran, D. P., Qi, H. Y., Geib, S. J., DeMello, N. C. · 1994; 116 (7): 3131–3132
Tritiated Methylene Diiodide — A New Synthetic Labeling Reagent
Journal of the Chemical Society, Chemical Communications
Saljoughian, M., Morimoto, H., Williams, P. G., DeMello, N. · 1990: 1652–1654

See Nick present at Open Education Week

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